Architecture and Analysis for Next Generation Mobile Signal Processing.

Mobile devices have proliferated at a spectacular rate, with more than 3.3 billion active cell phones in the world. With sales totaling hundreds of billions every year, the mobile phone has arguably become the dominant computing platform, replacing the personal computer. Soon, improvements to today’s smart phones, such as high-bandwidth internet access, high-definition video processing, and human-centric interfaces that integrate voice recognition and video-conferencing will be commonplace. Cost effective and power efficient support for these applications will be required. Looking forward to the next generation of mobile computing, computation requirements will increase by one to three orders of magnitude due to higher data rates, increased complexity algorithms, and greater computation diversity but the power requirements will be just as stringent to ensure reasonable battery lifetimes. The design of the next generation of mobile platforms must address three critical challenges: efficiency, programmability, and adaptivity. The computational efficiency of existing solutions is inadequate and straightforward scaling by increasing the number of cores or the amount of data-level parallelism will not suffice. Programmability provides the opportunity for a single platform to support multiple applications and even multiple standards within each application domain. Programmability also provides: faster time to market as hardware and software development can proceed in parallel; the ability to fix bugs and add features after manufacturing; and, higher chip volumes as a single platform can support a family of mobile devices. Lastly, hardware adaptivity is necessary to maintain efficiency as the computational characteristics of the applications change. Current solutions are tailored specifically for wireless signal processing algorithms, but lose their efficiency when other application domains like high definition video are processed. This thesis addresses these challenges by presenting analysis of next generation mobile signal processing applications and proposing an advanced signal processing architecture to deal with the stringent requirements. An application-centric design approach is taken to design our architecture. First, a next generation wireless protocol and high definition video is analyzed and algorithmic characterizations discussed. From these characterizations, key architectural implications are presented, which form the basis for the advanced signal processor architecture, AnySP.Ph.D.Electrical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/86344/1/mwoh_1.pd

Pangolin genomes and the evolution of mammalian scales and immunity

Pangolins, unique mammals with scales over most of their body, no teeth, poor vision, and an acute olfactory system, comprise the only placental order (Pholidota) without a whole-genome map. To investigate pangolin biology and evolution, we developed genome assemblies of the Malayan (Manis javanica) and Chinese (M. pentadactyla) pangolins. Strikingly, we found that interferon epsilon (IFNE), exclusively expressed in epithelial cells and important in skin and mucosal immunity, is pseudogenized in all African and Asian pangolin species that we examined, perhaps impacting resistance to infection. We propose that scale development was an innovation that provided protection against injuries or stress and reduced pangolin vulnerability to infection. Further evidence of specialized adaptations was evident from positively selected genes involving immunity-related pathways, inflammation, energy storage and metabolism, muscular and nervous systems, and scale/hair development. Olfactory receptor gene families are significantly expanded in pangolins, reflecting their well-developed olfaction system. This study provides insights into mammalian adaptation and functional diversification, new research tools and questions, and perhaps a new natural IFNE-deficient animal model for studying mammalian immunity.University of Malaya and Ministry of Education, Malaysia [UM.C/HIR/MOHE/08]; UMRG grant from the University of Malaya and Ministry of Education, Malaysia [RG541-13HTM]; Russian Ministry of Science [11.G34.31.0068]; NIH-NHGRI grant [5U54HG00307907]SCI(E)[email protected]

A depauperate immune repertoire precedes evolution of sociality in bees

Background Sociality has many rewards, but can also be dangerous, as high population density and low genetic diversity, common in social insects, is ideal for parasite transmission. Despite this risk, honeybees and other sequenced social insects have far fewer canonical immune genes relative to solitary insects. Social protection from infection, including behavioral responses, may explain this depauperate immune repertoire. Here, based on full genome sequences, we describe the immune repertoire of two ecologically and commercially important bumblebee species that diverged approximately 18 million years ago, the North American Bombus impatiens and European Bombus terrestris. Results We find that the immune systems of these bumblebees, two species of honeybee, and a solitary leafcutting bee, are strikingly similar. Transcriptional assays confirm the expression of many of these genes in an immunological context and more strongly in young queens than males, affirming Bateman’s principle of greater investment in female immunity. We find evidence of positive selection in genes encoding antiviral responses, components of the Toll and JAK/STAT pathways, and serine protease inhibitors in both social and solitary bees. Finally, we detect many genes across pathways that differ in selection between bumblebees and honeybees, or between the social and solitary clades. Conclusions The similarity in immune complement across a gradient of sociality suggests that a reduced immune repertoire predates the evolution of sociality in bees. The differences in selection on immune genes likely reflect divergent pressures exerted by parasites across social contexts

Sponge: Portable stream programming on graphics engines

Graphics processing units (GPUs) provide a low cost platform for accelerating high performance computations. The introduction of new programming languages, such as CUDA and OpenCL, makes GPU programming attractive to a wide variety of programmers. However, programming GPUs is still a cumbersome task for two primary reasons: tedious performance optimizations and lack of portability. First, optimizing an algorithm for a specific GPU is a time-consuming task that requires a thorough understanding of both the algorithm and the underlying hardware. Unoptimized CUDA programs typically only achieve a small fraction of the peak GPU performance. Second, GPU code lacks efficient portability as code written for one GPU can be inefficient when executed on another. Moving code from one GPU to another while maintaining the desired performance is a non-trivial task often requiring significant modifications to account for the hardware differences. In this work, we propose Sponge, a compilation framework for GPUs using synchronous data flow streaming languages. Sponge is capable of performing a wide variety of optimizations to generate efficient code for graphics engines. Sponge alleviates the problems associated with current GPU programming methods by providing portability across different generations of GPUs and CPUs, and a better abstraction of the hardware details, such as the memory hierarchy and threading model. Using streaming, we provide a writeonce software paradigm and rely on the compiler to automatically create optimized CUDA code for a wide variety of GPU targets. Sponge’s compiler optimizations improve the performance of the baseline CUDA implementations by an average of 3.2x

Eosinophilic Granulomatosis with Polyangitis (EGPA) with foot drop. A rare presentation of a rare disease

EGPA, previously known as Churg-Strauss Syndrome (CSS), is a rare, non-transmissible, medium and small vessel autoimmune vasculitis. We report a case of a 45-year-old lady whose initial presentation was left foot drop, which later on progressed to a sudden onset of vasculitic skin rashes at the background of longstanding poorly controlled bronchial asthm

Software Defined Radio - A High Performance Embedded Challenge

Wireless communication is one of the most computationally demanding workloads. It is performed by mobile terminals ("cell phones") and must be accomplished by a small battery powered system